3-羟基-2,2-二甲基-1-(1-甲基乙基)丙基异丁酸酯合成路线 （共 7 条）
反应条件
pyridine 1-oxide; dodecacarbonyltriiron in benzene T=80°C; 15 h; Yield given;
参考文献
Politechnika Opolska; Zak, Spolka Akcyjna
Patent: EP2436667 A1, 2012 ;
Location in patent: Page/Page column 3-5 ;
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With potassium hexamethylsilazane in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: isobutyraldehyde in tetrahydrofuran T=55°C; Inert atmosphere; Reagent/catalyst; Overall yield = 92.5 percent; Overall yield = 6.637 g;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
O2W(1-)*Li(1+) in tetrahydrofuran T=40°C; 24 h; variation of temperature; Yields of byproduct given;
参考文献
Villacorta, Gilberto M.; Filippo, Joseph San
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1151 - 1154
反应条件
sodium hydroxide in water T=60°C; 4 h; Concentration; Overall yield = 63.6 percentChromat.;
参考文献
Li, Yu-Gang; Luo, Chen-Xi; Qian, Chao; Chen, Xin-Zhi
Chemical Papers, 2014 , vol. 68, # 3 p. 422 - 426
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With n-butyllithium in tetrahydrofuran Inert atmosphere; 2: isobutyraldehyde in tetrahydrofuran 0.533333 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
1: With sodium hydroxide T=60°C; 4 h; 2: With hydrogenchloride Concentration; Overall yield = 85.4 percentChromat.;
参考文献
Li, Yu-Gang; Luo, Chen-Xi; Qian, Chao; Chen, Xin-Zhi
Chemical Papers, 2014 , vol. 68, # 3 p. 422 - 426
反应条件
1: With sodium hydroxide T=60°C; 4 h; 2: With hydrogenchloride Concentration; Overall yield = 59.3 percentChromat.;
参考文献
Li, Yu-Gang; Luo, Chen-Xi; Qian, Chao; Chen, Xin-Zhi
Chemical Papers, 2014 , vol. 68, # 3 p. 422 - 426
