反应条件
1: 1) EtMgBr, 2) CuCN / 1) THF, RT, 2h, 2) THF, 23h, reflux
2: 95 percent / diethyl ether / 0 °C
3: 53 percent / NaBD4, 2-methylbut-2-ene, BF3*OEt2 / bis-(2-methoxy-ethyl) ether / 1) 0 deg C, 30 min, 2) RT, 2h
4: 70 percent / KOH / ethanol; H2O / 1.5 h / Heating
View Scheme
参考文献
Crombie, Leslie; Morgan, David O.; Smith, Elisabeth H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 567 - 575
