N-[(1S)-1-甲基-2-(6-硝基-1H-苯并三唑-1-基)-2-硫酮乙基]氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
sodium nitrite in water; acetic acid T=0°C; 0.5 h;
参考文献
Ashraf Shalaby; Grote, Christopher W.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9045 - 9048
反应条件
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1) THF, -20 deg C, 10 min; 2) THF, -15 deg C, 2 h, rt, overnight 2: 88 percent / P4S10, Na2CO3 / tetrahydrofuran / 1) 0 deg C, 30 min, 2.) rt, 2.5 h 3: 79 percent / NaNO2 / acetic acid; H2O / 0.5 h / 0 °C View Scheme
参考文献
Ashraf Shalaby; Grote, Christopher W.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9045 - 9048
反应条件
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1) THF, -20 deg C, 10 min; 2) THF, -15 deg C, 2 h, rt, overnight 2: 88 percent / P4S10, Na2CO3 / tetrahydrofuran / 1) 0 deg C, 30 min, 2.) rt, 2.5 h 3: 79 percent / NaNO2 / acetic acid; H2O / 0.5 h / 0 °C View Scheme
参考文献
Ashraf Shalaby; Grote, Christopher W.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9045 - 9048
反应条件
1: 88 percent / P4S10, Na2CO3 / tetrahydrofuran / 1) 0 deg C, 30 min, 2.) rt, 2.5 h 2: 79 percent / NaNO2 / acetic acid; H2O / 0.5 h / 0 °C View Scheme
参考文献
Ashraf Shalaby; Grote, Christopher W.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9045 - 9048
