4-溴-2-(溴甲基)-1-甲氧基苯合成路线 （共 5 条）
反应条件
phosphorus tribromide in dichloromethane T=0°C; 0.25 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 73 ;
US 20070249607 A1
反应条件
N-bromosuccinmide in acetonitrile T=20°C; Wohl-Ziegler Bromination; 5 h; Irradiation; Concentration;
参考文献
Organic Letters, , vol. 15, # 16 p. 4194 - 4197
反应条件
1: ammonium hydroxide; iodine / 4 h / 20 - 60 °C 2: boron tribromide / dichloromethane / 5 h / 0 °C / |Reflux View Scheme
参考文献
Organic Letters, , vol. 15, # 16 p. 4194 - 4197
反应条件
ammonium hydroxide; iodine T=20 - 60°C; 4 h;
参考文献
Tsuchiya, Daisuke; Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo
Organic Letters, 2013 , vol. 15, # 16 p. 4194 - 4197
反应条件
1.1: [2,2']bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
2.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
2.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
