2-氯-3-溴-6-甲基吡啶合成路线 （共 4 条）
反应条件
1: 80.5 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 60 percent / aq. NaNO2, CuBr, HBr View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 32, # 10 p. 1173 - 1177
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: methanol / 168 h / Reflux 2: selenium(IV) oxide / dowtherm A / 3 h / 200 °C View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
反应条件
1: methanol / 168 h / Reflux 2: selenium(IV) oxide / dowtherm A / 3 h / 200 °C 3: toluene-4-sulfonic acid / 48 h / Reflux View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
