1: 105 °C 2: aq. NaOH solution View Scheme

palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=100°C; 19 h; Inert atmosphere;

palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=100°C; 19 h; Inert atmosphere;

1: copper(l) iodide; tetra-(n-butyl)ammonium iodide; caesium carbonate / acetonitrile / 72 h / 65 °C / Inert atmosphere 2: palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1,4-dioxane / 19 h / 100 °C / Inert atmosphere View Scheme

T=260 - 270°C; aza-Claisen rearrangement; 4 h;

hydrogenchloride; acetic acid T=120°C;

1: 67 percent / ethanol / 5 h / Heating 2: 3 percent / 4 h / 260 - 270 °C View Scheme