(2,3-二氢苯并[1,4]二恶烷-2-基)乙腈合成路线 （共 4 条）
反应条件
hydrogenchloride 20 h; Heating;
参考文献
Vazquez; Rosell; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 215 - 217
反应条件
1: 68 percent / HCl gas / 96 h / 5 °C
2: 2.) 4 N HCl / 1.) reflux, 18 h, 2.) 60 deg C, 24 h
3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min
View Scheme
参考文献
Caroon, Joan M.; Clark, Robin D.; Kluge, Arthur F.; Olah, Ronald; Repke, David B.; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 666 - 670
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
T=20°C; Catalytic hydrogenation; P=760 Torr;
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
diisobutylaluminium hydride in methanol; water; benzene
参考文献
Ciba-Geigy Corporation
Patent: US4104396 A1, 1978 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4129655 A1, 1978 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4039676 A1, 1977 ;
