2-氨基-3-(苯基甲基)-吡嗪合成路线 （共 5 条）
反应条件
1: toluene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane 0.5 h; Heating; 2: 2-amino-pyrazine in tetrahydrofuran; hexane T=0°C; 0.5 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
反应条件
1: pyridine; tetra-n-butylammonium tribromide / chloroform / 1 h / 20 °C 2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene; ethanol / Inert atmosphere; Reflux 3: hydrogenchloride / ethanol; water / Reflux View Scheme
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
反应条件
pyridine; tetra-n-butylammonium tribromide in chloroform T=20°C; 0.75 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
反应条件
1: 89 percent / tetra-n-butylammonium tribromide; pyridine / CHCl3 / 0.75 h / 20 °C
2: 88 percent / (PhCN)2PdCl2; 1,4-bis(diphenylphosphino)butane; Na2CO3 / toluene; ethanol; H2O / 4 h / Heating
3: 75 percent / pyridine hydrochloride / 0.5 h / Heating
View Scheme
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
反应条件
1: 89 percent / tetra-n-butylammonium tribromide; pyridine / CHCl3 / 0.75 h / 20 °C
2: 88 percent / (PhCN)2PdCl2; 1,4-bis(diphenylphosphino)butane; Na2CO3 / toluene; ethanol; H2O / 4 h / Heating
View Scheme
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
