二甲基(2R)-1,2-吡咯烷二羧酸酯合成路线 （共 3 条）
反应条件
potassium carbonate T=25°C; 12 h;
参考文献
Tsuda, Toshiro; Senba, Noriaki; Uratani, Takahiro
Patent: US2013/253228 A1, 2013 ;
Location in patent: Paragraph 0411; 0412; 0413 ;
反应条件
1: in tetrahydrofuran Heating; 2: With lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Wu, Xiaoyu; Liu, Xinyuan; Zhao, Gang
Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2299 - 2305
反应条件
1: 3,5-bis(trifluoromethyl)phenyl bromide With isopropylmagnesium chloride in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: 1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate in tetrahydrofuran T=0 - 65°C; Inert atmosphere;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 67-68 ;
US 20100190981 A1
