2-氯-6-氟-4-甲基喹啉合成路线 （共 3 条）
反应条件
phosphorus pentachloride; trichlorophosphate Chlorination; 12 h; Heating;
参考文献
Kato, Taka-Aki; Hakura, Atsushi; Mizutani, Takaharu; Saeki, Ken-Ichi
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000 , vol. 465, # 1-2 p. 173 - 182
反应条件
1.1: tetrahydrofuran / 24 h / Heating 1.2: 91 percent / conc. H2SO4 / 0.5 h / 80 °C 2.1: 99 percent / POCl3; PCl5 / 12 h / Heating View Scheme
参考文献
Kato, Taka-Aki; Hakura, Atsushi; Mizutani, Takaharu; Saeki, Ken-Ichi
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000 , vol. 465, # 1-2 p. 173 - 182
反应条件
1: 68 percent / conc. HCl, hydrazine hydrate / ethane-1,2-diol / Heating 2: 63 percent / acetic acid / ethanol / Heating 3: 48 percent / 10percent NaOH / methanol / Heating View Scheme
参考文献
Singh, S. P.; Vaid, R. K.; Prakash, I.; Prakash, O.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 945 - 950
