2,6-双[(3aS,8aR)-3a,8a-二氢-8H-indeno[1,2-d]恶唑啉-2-基]吡啶合成路线 （共 6 条）
反应条件
1: pyridine-2,6-dicarbonitrile With sodium in methanol 48 h; Inert atmosphere; 2: (1S,2R)-1-aminoindan-2-ol in dichloromethane T=40°C; 4 h; Inert atmosphere;
参考文献
Hanhan, Nadine V.; Ball-Jones, Nicolas R.; Tran, Ngon T.; Franz, Annaliese K.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 4 p. 989 - 992
反应条件
1: With potassium hydrogencarbonate in isopropanol acetate T=80°C; Substitution; 2: With boron trifluoride diethyl etherate T=125°C; Cyclization; Further stages.;
参考文献
Organic letters, , vol. 2, # 7 p. 1001 - 1004
反应条件
1: NaOCH3 / 36 h / 20 °C 2: CH2Cl2 / 48 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 27 p. 4543 - 4546
反应条件
1: 91 percent / KHCO3, isopropyl acetate / 65 °C 2: 73 percent / BF3*Et2O / 6 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 26 p. 9629 - 9630
反应条件
1: 91 percent / KHCO3, isopropyl acetate / 65 °C 2: 73 percent / BF3*Et2O / 6 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 26 p. 9629 - 9630
反应条件
in dichloromethane 48 h; Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 27 p. 4543 - 4546
