in water; acetic acid T=105°C; Hydrolysis;

1.1: 93 percent / H2O; acetic acid / 105 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 25 °C 2.2: t-BuLi / tetrahydrofuran / 0.92 h / -72 °C 2.3: 60 percent / tetrahydrofuran / 2.5 h / -72 °C View Scheme