1: 89.6 percent / 2-methyl-2-butene; H2O2; tetrabutylammonium hydroxide / 1,2-dimethoxy-ethane; H2O / 0.17 h / -10 °C 2: 94.6 percent / H2 / Pt/C / propan-2-ol / 2.5 h / 3800 Torr View Scheme

1: copper(l) chloride / tetrahydrofuran / 3.5 h / -40 °C / |Inert atmosphere 2: 4 h / 0 - 20 °C / |Inert atmosphere 3: ethylene glycol dimethyl ether / 6 h / 40 °C 4: potassium carbonate; dihydrogen peroxide / water; methanol; dimethyl sulfoxide / 1.5 h / 50 - 70 °C 5: acetic acid; methanesulfonic acid / 13 h / 40 - 105 °C View Scheme

1: N-Trimethylamine hydrochloride; triethylamine / toluene / 1 h / 0 °C 2: dimethyl sulfoxide / 24 h / 40 °C 3: potassium carbonate; dihydrogen peroxide / water; methanol; dimethyl sulfoxide / 1.5 h / 50 - 70 °C 4: acetic acid; methanesulfonic acid / 13 h / 40 - 105 °C View Scheme

1: 1,3-dimethyl-imidazolidin-2-one; lithium hydroxide hydrate / tetrahydrofuran / 14 h / 25 - 50 °C / |Inert atmosphere 2: potassium carbonate; dihydrogen peroxide / water; methanol; dimethyl sulfoxide / 1.5 h / 50 - 70 °C 3: acetic acid; methanesulfonic acid / 13 h / 40 - 105 °C View Scheme

1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 6 h / 20 °C 2: sodium chlorite; sodium dihydrogen phosphate monohydrate; cyclohexene / water; tert-butyl alcohol / 12 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3040.2 Torr View Scheme

1.1: acetic anhydride / |Inert atmosphere 1.2: |Inert atmosphere 1.3: |Inert atmosphere 2.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; NaClO2; NaClO / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / |Inert atmosphere View Scheme

1: potassium carbonate; dihydrogen peroxide / water; methanol; dimethyl sulfoxide / 1.5 h / 50 - 70 °C 2: acetic acid; methanesulfonic acid / 13 h / 40 - 105 °C View Scheme

1: hydrogenchloride / water; ethyl acetate; hexane / 0.5 h / |Large scale 2: platinum on carbon; hydrogen / isopropyl alcohol / 3.5 h / 30 °C / 3750.38 Torr / |Autoclave; |Large scale View Scheme

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere 1.2: 18 h / 20 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere 2.2: 0.08 h / Inert atmosphere 3.1: hydrogen / ethanol / 3 h / 760.05 Torr / Inert atmosphere 3.2: Inert atmosphere 4.1: sodium chlorite; sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / water; acetonitrile / 7 h / 35 °C / pH 6.7 / Inert atmosphere; aq. phosphate buffer 4.2: 0 °C / pH 8 / Inert atmosphere 4.3: pH 2 / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere 1.2: 0.08 h / Inert atmosphere 2.1: hydrogen / ethanol / 3 h / 760.05 Torr / Inert atmosphere 2.2: Inert atmosphere 3.1: sodium chlorite; sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / water; acetonitrile / 7 h / 35 °C / pH 6.7 / Inert atmosphere; aq. phosphate buffer 3.2: 0 °C / pH 8 / Inert atmosphere 3.3: pH 2 / Inert atmosphere View Scheme