3-(2-溴乙基)-5-甲氧基-1-甲基吲哚合成路线 （共 6 条）
反应条件
1: methyl iodide With sodium hydride in tetrahydrofuran T=20°C; 0.0833333 h; 2: 3-(2-bromoethyl)-5-methoxy indole in tetrahydrofuran T=20°C; 18 h;
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
Location in patent: Page/Page column 53 ;
WO 2012/110986 A1
反应条件
1: With tetrabutylammomium bromide; potassium hydroxide in dichloromethane; water T=-20°C; 5 h; 2: With bromine; triphenylphosphine in dichloromethane T=20°C; 6 h;
参考文献
Jafarpour, Farnaz; Hazrati, Hamideh
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 363 - 367
反应条件
1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 2.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1.1: diethyl ether / 3 h / 0 - 20 °C 2.1: triethylamine / 1 h / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C 4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 5.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C 2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 3.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1.1: triethylamine / 1 h / 0 - 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 4.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 4.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
