3-溴-4-甲氧基-苯丙酸合成路线 （共 6 条）
反应条件
sodium hydroxide in methanol; water T=20°C; Hydrolysis; 2.5 h;
参考文献
Bryant, Vashti C.; Kishore Kumar; Nyong, Abijah M.; Natarajan, Amarnath
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 245 - 248
反应条件
1: With potassium hydroxide in methanol; water 3 h; Heating / reflux; 2: Acidic aqueous solution;
参考文献
MERCK PATENT GMBH
Patent: WO2004/63148 A1, 2004 ;
Location in patent: Page 67-68 ;
反应条件
sodium hydroxide in methanol T=20°C; 2.5 h;
参考文献
Wong; Yu; Yuen; Yang
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3606 - 3609
反应条件
bromine in chloroform
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5922771 A1, 1999 ;
反应条件
1: 92 percent / Br2; AlCl3 / CH2Cl2 / 0.33 h / 0 °C 2: 98 percent / NaOH / methanol; H2O / 2.5 h / 20 °C View Scheme
参考文献
Bryant, Vashti C.; Kishore Kumar; Nyong, Abijah M.; Natarajan, Amarnath
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 245 - 248
反应条件
thionyl chloride; aluminium trichloride in water; 1,2-dichloro-ethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5922771 A1, 1999 ;
