in tetrahydrofuran; water T=0 - 65°C; 1 h; Product distribution / selectivity;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '14036784', constants.ctx, '0')">3-(carbamoylmethyl)-5-methylhexanoic acid</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587193', constants.ctx, '0')">bromine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128150', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=5 - 50&deg;C;&nbsp;Hofmann Reaction;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '2208678', constants.ctx, '0')">(S)-α-hydroxybenzeneacetic acid</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=20 - 22&deg;C;&nbsp;pH=4.5 - 5.5;&nbsp;&nbsp;Heating;&nbsp;<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br /> <br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635639', constants.ctx, '0')">isopropyl alcohol</a> <br />T=0 - 55&deg;C;&nbsp;&nbsp;Product distribution / selectivity;&nbsp;<br /> <br /> &nbsp;