(R)-2-甲基琥珀酸-4-叔丁酯合成路线 （共 13 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C; Hydrolysis; 2 h;
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 14 p. 2753 - 2768
反应条件
sulfuric acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; water; tert-butyl alcohol
反应条件
lithium hydroxide monohydrate; dihydrogen peroxide in tetrahydrofuran; water
反应条件
lithium hydroxide in tetrahydrofuran; water 3 h; Ambient temperature;
参考文献
Kubo, Akira; Kubota, Hitoshi; Takahashi, Masami; Nunami, Ken-Ichi
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5830 - 5837
反应条件
1: 97 percent / H2 / Pd/C / methanol / 3 h / Ambient temperature 2: 86 percent / dimethylsulfoxide / 1 h / 100 °C 3: 91 percent / H2SO4 / CH2Cl2 / 12 h / Ambient temperature 4: 79 percent / LiOH*H2O / tetrahydrofuran; H2O / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 5830 - 5837
反应条件
1.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C 1.2: 74 percent / tetrahydrofuran; toluene / 2 h / -78 °C 2.1: 68 percent / aq. H2O2; LiOH / tetrahydrofuran / 16 h / 0 - 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 14 p. 2753 - 2768
反应条件
1: 91 percent / H2SO4 / CH2Cl2 / 12 h / Ambient temperature 2: 79 percent / LiOH*H2O / tetrahydrofuran; H2O / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 5830 - 5837
反应条件
1: 86 percent / dimethylsulfoxide / 1 h / 100 °C 2: 91 percent / H2SO4 / CH2Cl2 / 12 h / Ambient temperature 3: 79 percent / LiOH*H2O / tetrahydrofuran; H2O / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 5830 - 5837
