N-(苯基甲基)-L-异亮氨酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water T=20°C; 0.5 h; 2: With sodium tetrahydroborate in water T=5 - 20°C; 3.5 h;
参考文献
Schmid, Rudolf; Zutter, Ulrich
Patent: US2005/272665 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
caesium carbonate in water; N,N-dimethyl-formamide T=23°C; 3.5 h;
参考文献
Salvatore, Ralph Nicholas; Nagle, Advait S.; Kyung, Woon Jung
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 674 - 683
反应条件
1: (methylation) 2: (hydrogenolysis) View Scheme
参考文献
Quitt,P. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 1715 - 1720
反应条件
tetraethylammonium hydroxide
参考文献
Guy, Laure; Vidal, Joelle; Collet, Andre; Amour, Augustin; Reboud-Ravaux, Michele
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4833 - 4843
反应条件
formic acid in water
T=90°C; 2 h;
参考文献
Schmid, Rudolf; Zutter, Ulrich
Patent: US2005/272665 A1, 2005 ;
Location in patent: Page/Page column 11 ;
参考文献
Quitt,P. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 1715 - 1720
