1-[2-(甲基氨基)苯基]乙酮合成路线 （共 15 条）
反应条件
sulfuric acid in acetic acid
参考文献
Kempter,G. et al.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1963 , vol. 3, p. 352 - 353
反应条件
1: (i) NaOMe, MeOH, toluene, (ii) /BRN= 635994/, (iii) aq. NaOH
2: aq. H2SO4 / acetic acid
View Scheme
参考文献
Kempter,G. et al.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1963 , vol. 3, p. 352 - 353
参考文献
Anderson, Gary B.; Yang, Lucie L.-N.; Falvey, Daniel E.
Journal of the American Chemical Society, 1993 , vol. 115, # 16 p. 7254 - 7262
反应条件
1: 1) p-TsOH, 2) H2, Raney nickel / 1) toluene, reflux, 2) EtOH, 5 bar, RT, 24h
2: 90 percent / H2, ammonium formate / 10percent Pd-C / methanol / Heating
View Scheme
参考文献
Bringmann, Gerhard; Geisler, Joerg-Peter; Geuder, Torsten; Kuenkel, Georg; Kinzinger Lioba
Liebigs Annalen der Chemie, 1990 , # 8 p. 795 - 805
反应条件
1: triethylamine / tetrahydrofuran / 3 h / 70 °C
2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 70 °C
View Scheme
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
