5-氨基-2-甲基苯甲酸甲酯合成路线 （共 13 条）
反应条件
palladium on activated charcoal; hydrogen in methanol T=20°C; 2 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18414 A2, 2004 ;
Location in patent: Page 110 ;
反应条件
1: 93 percent / H+ 2: 100 percent / H2 / Raney Nickel View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2823 - 2827
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=65°C; 1 h; 2: With Glauber's salt in tetrahydrofuran T=20°C;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2009/89042 A1, 2009 ;
Location in patent: Page/Page column 128 ;
WO 2009/089042 A1
反应条件
sulfuric acid; sodium nitrite Heating;
参考文献
Ray, Sutapa; Patra, Asit; Mal, Dipakranjan
Tetrahedron, 2008 , vol. 64, # 14 p. 3253 - 3267
反应条件
1: 66 percent / H2SO4; NaNO2 / Heating 2: 30 percent / PPA / Heating 3: 95 percent / Et2NPh / Heating 4: 86 percent / t-BuOLi / -60 - 20 °C 5: 81 percent / HBr; AcOH / Heating View Scheme
参考文献
Mal, Dipakranjan; Patra, Asit; Roy, Haren
Tetrahedron Letters, 2004 , vol. 45, # 42 p. 7895 - 7898
反应条件
1: methyl 5-amino-2-methylbenzoate With hydrogenchloride in water
T=5°C; Cooling with ice;
2: With sodium nitrite in water
T=5°C;
3: sodium cyanide; copper (I) cyanide in methanol; water
T=0 - 23°C;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; PURDUE RESEARCH FOUNDATION
Patent: US2011/269834 A1, 2011 ;
Location in patent: Page/Page column 29 ;
反应条件
1: methyl 5-amino-2-methylbenzoate With hydrogenchloride; sodium nitrite in methanol; water
T=0°C; 0.5 h;
2: copper (I) cyanide; potassium cyanide in water; ethyl acetate
0.5 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18414 A2, 2004 ;
Location in patent: Page 111 ;
反应条件
1: methyl 5-amino-2-methylbenzoate With hydrogenchloride; sodium nitrite
2: copper (I) cyanide With potassium cyanide in water
Further stages.;
参考文献
Thorarensen, Atli; Wakefield, Brian D.; Romero, Donna L.; Marotti, Keith R.; Sweeney, Michael T.; Zurenko, Gary E.; Rohrer, Douglas C.; Han, Fusen; Bryant Jr., Garold L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2823 - 2827
反应条件
1: 66 percent / H2SO4; NaNO2 / Heating
2: 30 percent / PPA / Heating
View Scheme
参考文献
Mal, Dipakranjan; Patra, Asit; Roy, Haren
Tetrahedron Letters, 2004 , vol. 45, # 42 p. 7895 - 7898
