2-氨基-6-甲基苯甲酸甲酯合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr;
参考文献
Pospisil, Jiri; Mueller, Christoph; Fuerstner, Alois
Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5956 - 5968
反应条件
in ethanol; hexane; ethyl acetate T=20°C; 1.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/37796 A1, 2005 ;
Location in patent: Page/Page column 122 ;
参考文献
Sterling Winthrop Inc.
Patent: US5512589 A1, 1996 ;
US 5512589 A
Title/Abstract Full Text Show Details
Sterling Winthrop Inc.
Patent: US5128339 A1, 1992 ;
US 5128339 A
Title/Abstract Full Text Show Details
Sterling Winthrop Inc.
Patent: US5385923 A1, 1995 ;
US 5385923 A
反应条件
hydrogenchloride; potassium fluoride; water in methanol 2 h; Heating;
参考文献
Boers, Rutger B.; Randulfe, Yolanda Pazos; Van Der Haas, Hendrikus N. S.; Van Rossum-Baan, Marleen; Lugtenburg, Johan
European Journal of Organic Chemistry, 2002 , # 13 p. 2094 - 2108
反应条件
1: 98 percent / K2CO3 / acetone / Heating 2: 100 percent / H2 / Pd/C / ethanol / 760 Torr View Scheme
参考文献
Mori, Keiji; Kurihara, Kazuki; Yabe, Shinnosuke; Yamanaka, Masahiro; Akiyama, Takahiko
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3744 - 3747
反应条件
in methanol T=20°C; 16 h;
参考文献
Jones, Alan M.; Lebl, Tomas; Patterson, Stephen; van Mourik, Tanja; Fruechtl, Herbert A.; Philp, Douglas; Slawin, Alexandra M.Z.; Westwood, Nicholas J.
Tetrahedron, 2009 , vol. 65, # 2 p. 563 - 578
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; water 2: 2-amino-6-methyl-benzoic acid in diethyl ether 1 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
in diethyl ether 1 h; Inert atmosphere;
参考文献
Levesque, Patrick; Fournier, Pierre-Andre
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7033 - 7036
反应条件
1.1: 75 percent / Red-Al / toluene / 3 h / Heating 2.1: H2SO4; NaNO2 / H2O / 0.08 h 2.2: 77 percent / CuSO4*5H2O; Cu2O / H2O / 0.75 h View Scheme
参考文献
European Journal of Organic Chemistry, , # 13 p. 2094 - 2108
反应条件
1: With hydrogen bromide; sodium nitrite Sandmeyer reaction; 2: With hydrogen bromide; copper(I) bromide T=0 - 20°C;
参考文献
Pospisil, Jiri; Mueller, Christoph; Fuerstner, Alois
Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5956 - 5968
