4-氨基-3-甲基苯甲酸甲酯合成路线 （共 34 条）
反应条件
1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
4: 90 percent / acetic acid / 2 h / Heating
5: 82.3 percent / NaOH; water / methanol / 2 h / Heating
6: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
2,6-dimethylpyridine in benzene
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 49 percent / 2,6-lutidine / benzene
2: 35 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 49 percent / 2,6-lutidine / benzene
2: 35 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
3: 80 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
