2-氨基-4-甲基苯甲酸甲酯合成路线 （共 8 条）
参考文献
Painter, Thomas O.; Kaszas, Krisztian; Gross, Jacklyn; Douglas, Justin T.; Day, Victor W.; Iadarola, Michael J.; Santini, Conrad
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 963 - 968
参考文献
Imperial Chemical Industries, PLC
Patent: US5599814 A1, 1997 ;
反应条件
in methanol; dichloromethane
反应条件
in diethyl ether 1 h; Inert atmosphere;
参考文献
Levesque, Patrick; Fournier, Pierre-Andre
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7033 - 7036
反应条件
1: methanol With iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid T=0°C; 0.166667 h; Inert atmosphere; 2: 5-methyl-isoindole-1,3-dione With 1,8-diazabicyclo[5.4.0]undec-7-ene T=0 - 40°C; Hofmann-type rearrangement; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Organic Letters, , vol. 14, # 3 p. 946 - 949
反应条件
dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 93, # 10 p. 914 - 915
反应条件
1: aqueous sulfuric acid; copper (II)-sulfate; water / Diazotization 2: aqueous KOH-solution View Scheme
参考文献
Mayer; Guenther
Chemische Berichte, 1930 , vol. 63, p. 1455,1462
反应条件
1: 75 percent / copper(II) acetate / dimethylformamide / 12 h / 100 °C
2: polyphosphoric ethyl ester / CHCl3 / 1 h / Heating
3: aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
参考文献
Rewcastle, Gordon W.; Denny, William A.
Synthesis, 1985 , # 2 p. 220 - 222
