3-氨基-4-甲基苯甲酸甲酯合成路线 （共 21 条）
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 0.25 h; Inert atmosphere; 2: With sodium hydrogencarbonate in 1,4-dioxane; water Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 43 p. 5625 - 5628
反应条件
hydrogenchloride; iron
反应条件
1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C 2: hydrogen; palladium on activated charcoal / methanol / 20 °C View Scheme
参考文献
EP2551262 A1, ;
EP 2551262 A1
反应条件
1.1: palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 °C / Inert atmosphere 2.2: Inert atmosphere View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 43 p. 5625 - 5628
反应条件
sulfuric acid Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 14 p. 6724 - 6731
反应条件
1: H2SO4; aqueous HNO3 2: iron; aqueous HCl View Scheme
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite in water T=0 - 20°C; 2 h; 2: With potassium iodide in water 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/3998 A2, 2009 ;
Location in patent: Page/Page column 30-31 ;
反应条件
lithium borohydride in diethylene glycol dimethyl ether; water
参考文献
Smith Kline and French Laboratories, Ltd.
Patent: US5082848 A1, 1992 ;
US 5082848 A
反应条件
1.1: tetrahydrofuran / 36 h / Reflux 2.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 20 °C 2.2: 0 °C View Scheme
参考文献
Dominique, Romyr; Luk, Kin-Chun; Qiao, Qi; Rossman, Pamela Loreen
Patent: US2012/184548 A1, 2012 ;
US 20120184548 A1
反应条件
1: sodium nitrite / water; acetic acid / 24 h / 0 - 20 °C 2: potassium hydroxide; iodine / isobutyramide / 1 h / 0 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; BARR, Kenneth Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; ZHANG, Dongshan
Patent: WO2014/26327 A1, 2014 ;
