反应条件
1: 1,2-dichloro-benzene / 150 - 160 °C 2: bromine; acetic acid / 5 °C 3: potassium carbonate / N,N-dimethyl-formamide / 20 - 25 °C 4: lithium hydroxide hydrate / tetrahydrofuran / 20 - 25 °C 5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 25 °C View Scheme
参考文献
Selness, Shaun R.; Devraj, Rajesh V.; Devadas, Balekudru; Walker, John K.; Boehm, Terri L.; Durley, Richard C.; Shieh, Huey; Xing, Li; Rucker, Paul V.; Jerome, Kevin D.; Benson, Alan G.; Marrufo, Laura D.; Madsen, Heather M.; Hitchcock, Jeff; Owen, Tom J.; Christie, Lance; Promo, Michele A.; Hickory, Brian S.; Alvira, Edgardo; Naing, Win; Blevis-Bal, Radhika; Messing, Dean; Yang, Jerry; Mao, Michael K.; Yalamanchili, Gopi; Vonder Embse, Richard; Hirsch, Jeffrey; Saabye, Matthew; Bonar, Sheri; Webb, Elizabeth; Anderson, Gary; Monahan, Joseph B.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 13 p. 4066 - 4071