3-苄氧基-4-甲氧苄醇合成路线 （共 20 条）
反应条件
1: NEt3 / CH2Cl2 2: dimethylformamide 3: 70 percent / 30 percent aq. NaOH / Heating View Scheme
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1940 , vol. 544, p. 30,58
反应条件
1: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C 2: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 3: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 4: K2CO3 / acetone / 14 h / Heating 5: lithium aluminum hydride / tetrahydrofuran / Heating 6: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme
参考文献
Meyers, A. I.; Guiles, Joseph
Heterocycles, 1989 , vol. 28, # 1 p. 295 - 301
反应条件
Mortierella isabellina NRRL 1757 Ambient temperature;
参考文献
Holland, Herbert L.; Conn, Morgan; Chenchaiah, P. Chinna; Brown, Frances M.
Tetrahedron Letters, 1988 , vol. 29, # 49 p. 6393 - 6394
反应条件
1: SOCl2 / diethyl ether 2: NaI, NaCN / butan-2-one 3: aq. KOH / methanol; dioxane 4: H2 / Pd-C / methanol View Scheme
参考文献
Kupchan,S.M.; Yoshitake,A.
Journal of Organic Chemistry, 1969 , vol. 34, # 4 p. 1062 - 1065
反应条件
thionyl chloride in dichloromethane 0.5 h;
参考文献
EURO-CELTIQUE S.A.
Patent: EP1202628 B1, 2004 ;
Location in patent: Page 11 ;
EP 1202628 B1
反应条件
1: 85 percent / SOCl2 / dioxane / 1 h / 20 °C 2: 70 percent / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: 88 percent / PBr3 / benzene / 0.5 h / 5 °C
2: 50 percent / n-butyl lithium / tetrahydrofuran / 3 h / -30 °C
3: mercuric chloride / methanol; tetrahydrofuran / 24 h / 130 °C
4: trifluoroacetic acid / 3 h / Ambient temperature
View Scheme
参考文献
Annapurna, G. S.; Deshpande, V. H.
Synthetic Communications, 1983 , vol. 13, # 13 p. 1075 - 1082
反应条件
1: SOCl2
3: HCl / ethanol
View Scheme
参考文献
Bhandari, Prabha; Crombie, Leslie; Daniels, Peter; Holden, Ian; Bruggen, Nicholas Van; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 7 p. 839 - 850
反应条件
phosphorus tribromide in tetrahydrofuran
T=0°C; 1.5 h;
参考文献
Potter, Barry Victor Lloyd; Woo, Lok Wai Lawrence; Purohit, Atul; Reed, Michael John; Sutcliffe, Oliver Brook; Bubert, Christian
Patent: US2004/19016 A1, 2004 ;
Location in patent: Page/Page column 47 ;
反应条件
1: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
2: 18-crown-6 / acetonitrile / 7 h / Heating
3: aq. KOH / ethanol / 4 h / Heating
4: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1940 , vol. 544, p. 30,58
