(1-氰基-3-甲基丁基)丙二酸二乙酯合成路线 （共 6 条）
反应条件
1: With ethanol; sodium ethanolate T=80°C; 20 h; 2: With acetic acid in ethanol T=20°C;
参考文献
Hu, Shanghui; Martinez, Carlos Alberto; Tao, Junhua; Tully, William Eugene; Kelleher, Patrick; Dumond, Yves
Patent: US2005/283023 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
in ethanol T=25 - 35°C; 2 - 3 h;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62460 A2, 2008 ;
Location in patent: Page/Page column 18-20 ;
反应条件
water; BnQN+Cl- in toluene T=20°C;
参考文献
PFIZER IRELAND PHARMACEUTICALS; DAVIES, Benjamin, Simon; GUZMAN, Mark, M.; MARTINEZ, Carlos, A.; McDAID, Paul, Oliver; O'NEILL, Padraig, Mary; SHANMUGAM, Elango
Patent: WO2010/70593 A2, 2010 ;
Location in patent: Page/Page column 28-32 ;
反应条件
in ethanol T=25 - 42°C; Product distribution / selectivity;
参考文献
PFIZER IRELAND PHARMACEUTICALS; DAVIES, Benjamin, Simon; GUZMAN, Mark, M.; MARTINEZ, Carlos, A.; McDAID, Paul, Oliver; O'NEILL, Padraig, Mary; SHANMUGAM, Elango
Patent: WO2010/70593 A2, 2010 ;
Location in patent: Page/Page column 28-32 ;
反应条件
potassium carbonate in ethanol T=20°C; 12 h;
参考文献
Wang, Jun; Li, Wei; Liu, Yanling; Chu, Yangyang; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming
Organic Letters, 2010 , vol. 12, # 6 p. 1280 - 1283
反应条件
1.1: calcium acetate bihydrate; sodium hydroxide / water / 24 h 1.2: 3 h / 85 °C / |Inert atmosphere 2.1: potassium hydroxide / water; isopropanol acetate / 1 h / 20 °C 2.2: 5 h View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 3 p. 392 - 398
