diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; Reduction; 0.75 h;

1: 96 percent / H2 / Pd/C / methanol / 20 °C 2: 92 percent / Et3N / dimethylformamide / 20 °C 3: 100 percent / DIBAL-H / CH2Cl2; toluene / 0.75 h / -78 °C View Scheme

1: 99 percent / Na2SO4; conc. h2SO4 / 30 h / Heating 2: 96 percent / H2 / Pd/C / methanol / 20 °C 3: 92 percent / Et3N / dimethylformamide / 20 °C 4: 100 percent / DIBAL-H / CH2Cl2; toluene / 0.75 h / -78 °C View Scheme

1: 92 percent / Et3N / dimethylformamide / 20 °C 2: 100 percent / DIBAL-H / CH2Cl2; toluene / 0.75 h / -78 °C View Scheme

1: 3-(1-tritylimidazol-4-yl)propionaldehyde With ammonium hydroxide; ammonium chloride in methanol T=20°C; Addition; 0.666667 h; 2: potassium cyanide T=20°C; Condensation; Strecker reaction; 18 h; Further stages.;