1-甲基-1H-吲哚-5-甲酸合成路线 （共 11 条）
反应条件
hydrogenchloride; sodium hydroxide in THF (50 mL)-MeOH
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1479384 A1, 2004 ;
反应条件
1: 1H-Indole-5-carboxylic acid With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=20°C; 3 h;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2108642 A1, 2009 ;
Location in patent: Page/Page column 79 ;
反应条件
in tetrahydrofuran T=1°C; 0.0833333 h;
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron, 2005 , vol. 61, # 47 p. 11168 - 11176
反应条件
in N,N-dimethyl-formamide
反应条件
in tetrahydrofuran T=1°C; 0.0833333 h;
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron, 2005 , vol. 61, # 47 p. 11168 - 11176
反应条件
1: magnesium / tetrahydrofuran / 0.5 h / 120 °C / microwave irradiation 2: 84 percent / tetrahydrofuran / 0.08 h / 1 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 47 p. 11168 - 11176
反应条件
1: magnesium; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / 200 °C / microwave irradiation 2: 48 percent / tetrahydrofuran / 0.08 h / 1 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 47 p. 11168 - 11176
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: dimethylformamide / 2.5 h / 0 - 20 °C 2.1: NaOH / methanol; H2O / 8 h / Heating View Scheme
参考文献
Heterocycles, , vol. 67, # 2 p. 643 - 653
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: dimethylformamide / 2.5 h / 0 - 20 °C 2.1: NaOH / ethanol; H2O / 8 h / Heating View Scheme
参考文献
Heterocycles, , vol. 67, # 2 p. 643 - 653
反应条件
1: triethylamine; diphenylphosphorazidate / benzene / 1 h / 20 °C
2: chlorobenzene / 1 h / Heating
View Scheme
参考文献
Rigby, James H.; Burke, Patrick J.
Heterocycles, 2006 , vol. 67, # 2 p. 643 - 653
