3-氰基-1,2-二氢-6-甲基-2-氧代-4-吡啶羧酸乙酯合成路线 （共 25 条）
反应条件
diethylamine in ethanol T=60°C; Guareschi-Thorpe reaction;
参考文献
Schmidt, Gunther; Reber, Stefan; Bolli, Martin H.; Abele, Stefan
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 595 - 604
反应条件
piperidine in ethanol T=80°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 156 - 160
参考文献
Journal of the Chemical Society, , p. 2229
反应条件
ethanol; diethylamine
参考文献
Annali di Chimica (Rome, Italy), , vol. 47, p. 385,391
反应条件
1: PCl5; POCl3 2: palladium/BaCO3; ethanol / Hydrogenation 3: ethanolic NaOH 4: copper-powder View Scheme
参考文献
Reider; Elderfield
Journal of Organic Chemistry, 1942 , vol. 7, p. 286,295
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Yu, Ming; Zhang, Jian; Wang, Yingcai; Zhu, Jiang; Kayser, Frank; Medina, Julio C.; Siegler, Karen; Conn, Marion; Shan, Bei; Grillo, Mark P.; Coward, Peter; Liu, Jiwen
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 156 - 160
反应条件
1: hydrogenchloride; water / 24 h / 115 °C / Inert atmosphere 2: trichlorophosphate / 18 h / Inert atmosphere; Reflux 3: 24 h / -5 - 20 °C / Inert atmosphere View Scheme
参考文献
Libermann et al.
Bulletin de la Societe Chimique de France, 1958 , p. 687,691
反应条件
1: aqueous HCl 2: diethyl ether View Scheme
参考文献
Musante; Fatutta
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 385,391
参考文献
Libermann et al.
Bulletin de la Societe Chimique de France, 1958 , p. 687,691
Full Text Show Details
Musante; Fatutta
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 385,391
反应条件
1: HNO3, / acetic anhydride 2: PCl3 / chlorobenzene View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
