3-氰基-1,2-二氢-6-甲基-2-氧代-4-吡啶羧酸乙酯合成路线 （共 25 条）
反应条件
1: PCl5; POCl3
2: aqueous NH3
3: aqueous HCl
View Scheme
参考文献
Reider; Elderfield
Journal of Organic Chemistry, 1942 , vol. 7, p. 286,295
反应条件
1: urea; acetic acid anhydride; HNO3
2: POCl3; PCl5 / 120 - 130 °C
3: palladium/BaCO3; ethanol / 36775.4 - 44130.5 Torr / Hydrogenation
4: concentrated aqueous HCl
5: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
6: diethyl ether; methanol / -15 °C
7: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
nitric acid; acetic anhydride; urea
参考文献
Pieper; Yang; Zhou; Liu
Journal of the American Chemical Society, 1997 , vol. 119, # 8 p. 1809 - 1817
反应条件
1: urea; acetic acid anhydride; HNO3
2: chlorobenzene; PCl5
3: SnCl2; concentrated aqueous HCl; acetic acid
4: palladium/BaSO4; ethanol / Hydrogenation
5: concentrated aqueous HCl
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: dichlorophenyl phosphine oxide / 150 °C
2: sulfuric acid / 80 °C
View Scheme
参考文献
Yu, Ming; Zhang, Jian; Wang, Yingcai; Zhu, Jiang; Kayser, Frank; Medina, Julio C.; Siegler, Karen; Conn, Marion; Shan, Bei; Grillo, Mark P.; Coward, Peter; Liu, Jiwen
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 156 - 160
