2-Boc-5-苄基六氢吡咯并[3,4-c]吡咯合成路线 （共 6 条）
反应条件
in tetrahydrofuran T=20°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/121145 A2, 2005 ;
Location in patent: Page/Page column 150-151 ;
WO 2005/121145 A2
反应条件
1: 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 7.3 h; 2: With sodium sulfate T=0 - 20°C; 16 h; 3: di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 16 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.
Patent: US2005/65178 A1, 2005 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium hydroxide in methanol; water T=20°C; pH=10; 18.5 h;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 25 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / |Reflux 2: dichloromethane / 0 - 20 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1: trifluoroacetic acid / dichloromethane / 6 h / -5 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / |Reflux 3: dichloromethane / 0 - 20 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol T=50°C; P=3102.97 Torr; 2.5 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 28 ;
