4-苯基-3,6-二氢-2H-吡啶-1-羧酸叔丁酯合成路线 （共 19 条）
反应条件
1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: HCl 2: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 22 p. 3951 - 3954
反应条件
palladium on activated charcoal; hydrogen in methanol T=20°C; 15 h;
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran
T=20°C; 19 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
1: bromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane
T=20°C; 2 h;
3: With methanesulfonyl chloride; triethylamine in tetrahydrofuran; hexane
T=-78 - 20°C; 15 h;
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
N,N,N',N,-tetramethylethylenediamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=40°C; 1 h;
参考文献
Larsen, Uffe S.; Martiny, Lars; Begtrup, Mikael
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4261 - 4263
反应条件
N,N,N',N,-tetramethylethylenediamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=40°C; 1 h;
参考文献
Larsen, Uffe S.; Martiny, Lars; Begtrup, Mikael
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4261 - 4263
反应条件
potassium fluoride; biphenyl-2-yl-di-tert-butyl-phosphane; palladium diacetate in ethylene glycol dimethyl ether; water
T=150°C; Suzuki cross-coupling reaction; 0.0833333 h; microwave irradiation;
参考文献
Larsen, Uffe S.; Martiny, Lars; Begtrup, Mikael
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4261 - 4263
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile
参考文献
Bursavich; West; Rich
Organic letters, 2001 , vol. 3, # 15 p. 2317 - 2320
反应条件
1-methyl-pyrrolidin-2-one; iron (III) acetylacetonate in tetrahydrofuran
T=-30°C;
参考文献
Scheiper, Bodo; Bonnekessel, Melanie; Krause, Helga; Fuerstner, Alois
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3943 - 3949
