1,2,3,4-四氢-6-硝基异喹啉合成路线 （共 17 条）
反应条件
1.1: aq. NaNO2; aq. HCl / 2 h / 0 °C 1.2: 65 percent / aq. H3PO2 / 10 h / 40 °C 2.1: aq. HCl / methanol / 10 h / Heating View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1: 89 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 16 h / 25 °C 2: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 3: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 2: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1: ethyl acetate / 6 h / 65 °C 2: 89 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 16 h / 25 °C 3: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 4: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1: NaOH / methanol; H2O / 3 h / Ambient temperature 2: ethyl acetate / 6 h / 65 °C 3: 89 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 16 h / 25 °C 4: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 5: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
iron; ammonium chloride in ethanol; water T=60°C; 24 h;
参考文献
CELLZOME AG
Patent: WO2009/62658 A1, 2009 ;
Location in patent: Page/Page column 37 ;
WO 2009/062658 A1
反应条件
iron; ammonium chloride in ethanol; water T=60°C; 24 h;
参考文献
CELLZOME AG
Patent: WO2009/62658 A1, 2009 ;
Location in patent: Page/Page column 37 ;
WO 2009/062658 A1
