1: 87 percent / NaNO2, aq. AcOH / 3 h / 0 - 5 °C 2: 78 percent / 1N aq. HCl / 3 h / Heating View Scheme

1: conc. HCl / N,N-dimethyl-acetamide / Ambient temperature 2: 55 percent / CH2I2, CuI / tetrahydrofuran / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8973685', constants.ctx, '0')">zinc</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />4&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: K₂CO₃ / ethanol / Heating<br />2: sodium acetate / acetic acid; H₂O<br />3: Zn, CH₃COOH / ethanol; H₂O / 60 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 80 percent / Et₃N / butan-1-ol / 48 h / Heating<br />2: 1.) conc. aq. HCl, NaNO₂, 2.) NaOAc, aq. AcOH / 1.) 0 deg C, 15 min, 2.) RT, 24 h<br />3: 22 percent / Zn, aq. AcOH / ethanol / 4 h / Heating<br /> <br /> &nbsp;