(3beta)-3-(乙酰氧基)-17-氯雄甾-5,16-二烯-16-甲醛合成路线 （共 7 条）
反应条件
trichlorophosphate in chloroform 5 h; Cooling with iceRefluxInert atmosphere;
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing; YE, Tao
Patent: WO2012/83112 A2, 2012 ;
Location in patent: Page/Page column 181 ;
WO 2012/083112 A2
反应条件
trichlorophosphate in chloroform 5 h; Heating;
参考文献
UNIVERSITY OF MARYLAND
Patent: WO2006/93993 A1, 2006 ;
Location in patent: Page/Page column 26; 44 ;
WO 2006/093993 A1
反应条件
N,N-dimethyl-formamide; trichlorophosphate in chloroform 5 h; Heating;
参考文献
Njar, Vincent C. O.; Kato, Katsuya; Nnane, Ivo P.; Grigoryev, Dmitry N.; Long, Brian J.; Brodie, Angela M. H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 902 - 912
反应条件
1.1: pyridine 2.1: POCl3 / CH2Cl2 / 0.33 h / 20 °C 2.2: 3.4 g / CH2Cl2 / 96 h / 45 - 50 °C View Scheme
参考文献
Zhang, Bao-Le; Zhang, En; Pang, Lu-Ping; Song, Li-Xing; Li, Ya-Fei; Yu, Bin; Liu, Hong-Min
Steroids, 2013 , vol. 78, # 12-13 p. 1200 - 1208
反应条件
1: (4-morpholinyl)methanone With trichlorophosphate in dichloromethane T=20°C; 0.333333 h; 2: 3β-hydroxyandrost-5-en-17-one acetate in dichloromethane T=45 - 50°C; Vilsmeier reaction; 96 h;
参考文献
Dalmaris, John; Hanson, James R.; Hitchcock, Peter B.; Kiran, Ismail
Journal of Chemical Research - Part S, 2003 , # 3 p. 150 - 152
反应条件
1: 88.7 percent / K2CO3 / dimethylformamide / 1.5 h / 80 °C 2: 73.8 percent / Pd/C; benzonitrile / 5 h / Heating 3: 94 percent / KOH / methanol / 1.5 h / 20 °C View Scheme
参考文献
Handratta, Venkatesh D.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Gediya, Lalji K.; Kataria, Ritesh; Chopra, Pankaj; Newman Jr., Donnell; Farquhar, Rena; Guo, Zhiyong; Qiu, Yun; Brodie, Angela M. H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2972 - 2984
反应条件
1: 88.7 percent / K2CO3 / dimethylformamide / 1.5 h / 80 °C
2: 73.8 percent / Pd/C; benzonitrile / 5 h / Heating
View Scheme
参考文献
Handratta, Venkatesh D.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Gediya, Lalji K.; Kataria, Ritesh; Chopra, Pankaj; Newman Jr., Donnell; Farquhar, Rena; Guo, Zhiyong; Qiu, Yun; Brodie, Angela M. H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2972 - 2984
