(3S)-3-boc-氨基-1-二氮杂-2-丁酮合成路线

参考文献

MERCK SHARP and DOHME CORP.; MERCK CANADA INC.; MACHACEK, Michele, R.; ALTMAN, Michael, D.; ROMEO, Eric, T.; VITHARANA, Dilrukshi; CASH, Brandon; SIU, Tony; ZHOU, Hua; CHRISTOPHER, Matthew; KATTAR, Solomon, D.; HAIDLE, Andrew, M.; CHILDERS, Kaleen Konrad; MADDESS, Matthew, L.; REUTERSHAN, Michael, H.; DUCHARME, Yves; GUERIN, David. J.; SPENCER, Kerrie; BEAULIEU, Christian; TRUONG, Vouy Linh; GUAY, Daniel; NORTHRUP, Alan, B.; TAOKA, Brandon, M.; LIM, Jongwon; FISCHER, Christian; BUTCHER, John, W.; OTTE, Ryan, D.; SUN, Binyuan
Patent: WO2013/192125 A1, 2013 ;
Location in patent: Page/Page column 140 ;

186581-53-3重氮甲烷+

3744-87-4BOC-DL-丙氨酸

186521-98-2(3S)-3-boc-氨基-1-二氮杂-2-丁酮

参考文献

Trinh, Thi Thanh Huyen; Nguyen, Khanh Hung; De Aguiar Amaral, Patricia; Gouault, Nicolas
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2042 - 2047

3744-87-4BOC-DL-丙氨酸

186521-98-2(3S)-3-boc-氨基-1-二氮杂-2-丁酮

参考文献

Podwysocka; Kosson; Lipkowski; Olma, Aleksandra
Journal of Peptide Science, 2012 , vol. 18, # 9 p. 556 - 559

186581-53-3重氮甲烷

186521-98-2(3S)-3-boc-氨基-1-二氮杂-2-丁酮

参考文献

Podwysocka; Kosson; Lipkowski; Olma, Aleksandra
Journal of Peptide Science, 2012 , vol. 18, # 9 p. 556 - 559

67-56-1甲醇+

186521-98-2(3S)-3-boc-氨基-1-二氮杂-2-丁酮

159877-47-1(r)-n-boc-3-氨基丁酸甲酯

参考文献

Czekaj, Mark; Klein, Scott I.; Guertin, Kevin R.; Gardner, Charles J.; Zulli, Allison L.; Pauls, Henry W.; Spada, Alfred P.; Cheney, Daniel L.; Brown, Karen D.; Colussi, Dennis J.; Chu, Valeria; Leadley, Robert J.; Dunwiddie, Christopher T.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 12 p. 1667 - 1670

186521-98-2(3S)-3-boc-氨基-1-二氮杂-2-丁酮

159991-23-8(3R)-3-[[(1,1-二甲基乙炔氧基)羰基]氨基]-丁酸

参考文献

Seebach, Dieter; Ciceri, Paola E.; Overhand, Mark; Jaun, Bernhard; Rigo, Dario; Oberer, Lukas; Hommel, Ulrich; Amstutz, Rene; Widmer, Hans
Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2043 - 2066