3-(3-氯苯基)-1-丙胺合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 47 h; 2: With water in tetrahydrofuran
参考文献
Pfizer Inc.
Patent: US6288120 B1, 2001 ;
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; N-methyl-acetamide; diethyl ether
参考文献
NPS Pharmaceuticals, Inc.
Patent: US6211244 B1, 2001 ;
US 6211244 B1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Dukat, Malgorzata; Abdel-Rahman, Ashraf A.; Ismaiel, Abd M.; Ingher, Stacy; Teitler, Milt; Gyermek, Laszlo; Glennon, Richard A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4017 - 4026
反应条件
1: 89 percent / 48percent aq. HBr, H2SO4 / 3 h / Heating 2: 58 percent / methanol; H2O / 0.5 h / Heating 3: 44 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Dukat, Malgorzata; Abdel-Rahman, Ashraf A.; Ismaiel, Abd M.; Ingher, Stacy; Teitler, Milt; Gyermek, Laszlo; Glennon, Richard A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4017 - 4026
反应条件
1: 58 percent / methanol; H2O / 0.5 h / Heating 2: 44 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Dukat, Malgorzata; Abdel-Rahman, Ashraf A.; Ismaiel, Abd M.; Ingher, Stacy; Teitler, Milt; Gyermek, Laszlo; Glennon, Richard A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4017 - 4026
