1-Boc-3-氨基吡咯烷合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr;
参考文献
GRUeNENTHAL GMBH
Patent: WO2005/77924 A1, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/077924 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol 3 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 67 ;
EP 1500643 A1
反应条件
hydrogen; palladium on activated charcoal in methanol P=26600 Torr; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
in chloroform T=20°C; 1 h;
参考文献
PFIZER INC.
Patent: WO2004/74283 A1, 2004 ;
Location in patent: Page 38 ;
WO 2004/074283 A1
反应条件
in N,N-dimethyl-formamide 24 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/47240 A1, 2009 ;
Location in patent: Page/Page column 92-93 ;
WO 2009/047240 A1
反应条件
1: Et3N; DPPA / toluene / 1 h / Heating 2: toluene / 14 h / Heating 3: H2 / 10 percent Pd/C / methanol / 5 h / 26600 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
1: 85 percent / aq. NaOH / methanol / 72 h / 20 °C 2: Et3N; DPPA / toluene / 1 h / Heating 3: toluene / 14 h / Heating 4: H2 / 10 percent Pd/C / methanol / 5 h / 26600 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
sodium hydroxide in water; isopropyl alcohol pH=6.0;
参考文献
Shchekotikhin, Andrey E.; Glazunova, Valeria A.; Luzikov, Yuri N.; Buyanov, Vladimir N.; Susova, Olga Yu.; Shtil, Alexander A.; Preobrazhenskaya, Maria N.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5241 - 5251
反应条件
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 7 h / 0 - 20 °C 1.2: 0 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 16 h View Scheme
参考文献
WO2011/30349 A1, ;
WO 2011/030349 A1
反应条件
ω-transaminase from Alcaligenes denitrificans; pyridoxal 5'-phosphate; 2-oxo-propionic acid in sodium phosphate buffer T=37°C; pH=8; 7 h; kinetic resolutionEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 6 p. 807 - 812
