3-溴-2-甲基-5-硝基吡啶合成路线 （共 4 条）
反应条件
1: diethyl malonate With sodium hydride in diethyl ether T=15°C; 0.0833333 h; 2: 3-Bromo-2-chloro-5-nitropyridine in diethyl ether T=26 - 114°C; 1.5 h; 3: With sulfuric acid in water 8 h; Heating / reflux;
参考文献
H. Lundbeck A/S
Patent: US2006/79524 A1, 2006 ;
Location in patent: Page/Page column 13 ;
US 20060079524 A1
反应条件
sodium hydroxide in diethyl ether; mineral oil
参考文献
Abbott Laboratories
Patent: US6127386 A1, 2000 ;
US 6127386 A
反应条件
in water; acetic acid
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
