3-氧代-1,2,3,4-四氢-6-喹喔啉甲腈合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate in methanol; Pd on carbon; ethanol; ethyl acetate
参考文献
DuPont Pharmaceuticals Company
Patent: US6207697 B1, 2001 ;
反应条件
sodium dithionite in water T=100°C; 1 h;
参考文献
Cai, Sui Xiong; Kher, Sunil M.; Zhou, Zhang-Lin; Ilyin, Victor; Espitia, Stephen A.; Tran, Minhtam; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 730 - 738
反应条件
1: aq. ethanol / 48 h / Heating 2: Na2S2O4 / H2O / 1 h / 100 °C View Scheme
参考文献
DAIICHI SANKYO COMPANY, LIMITED; KATOCH, Rita; INAGAKI, Hiroaki; FUJISAWA, Tetsunori
Patent: WO2014/24056 A1, 2014 ;
反应条件
1: nitronium tetrafluoroborate / acetonitrile / 20 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 125 °C / |Microwave irradiation 3: hydrogen; 30 Pd/C / methanol / 1.5 h 4: ethanol; acetic acid / 1 h / 80 °C View Scheme
参考文献
DAIICHI SANKYO COMPANY, LIMITED; KATOCH, Rita; INAGAKI, Hiroaki; FUJISAWA, Tetsunori
Patent: WO2014/24056 A1, 2014 ;
