反应条件
1: 94 percent / SO3*pyridine, DMSO, Et3N / CH2Cl2 / 0.5 h / 25 °C
2: 1) LDA / 1) THF, -78 deg C, 15 min; -40 deg C, 0.5 h, 2) THF, -78 deg C, 15 min
3: 2,6-lutidine / CH2Cl2 / 2 h / 0 °C
4: 1.1 g / K2CO3 / methanol / 0.25 h / 25 °C
5: 78 percent / TBAF / tetrahydrofuran / 8 h / 25 °C
6: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-DMAP / 1) THF, 0 deg C, 15 min, 2) toluene, 25 deg C, 0.5 h
7: 92 percent / CF3CO2H / CH2Cl2 / 1) -20 deg C -> 0 deg C, 2) 0 deg C, 1 h
View Scheme
参考文献
Nicolaou; Ninkovic; Sarabia; Vourloumis; He; Vallberg; Finlay; Yang
Journal of the American Chemical Society, 1997 , vol. 119, # 34 p. 7974 - 7991
