反应条件
1: 74 percent / diethyl ether / 0.5 h / -100 °C
2: 98 percent / 2,6-lutidine / CH2Cl2 / 0.75 h / -78 °C
3: 1) O3, 2) PPh3 / 1) CH2Cl2, -78 deg C, 30 min, 2) Ch2Cl2, -78 deg C -> room temperature; room temperature, 1 h
4: 93 percent / NaClO2, 2-methyl-2-butene, NaH2PO4 / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 4 h / Ambient temperature
5: 1) LDA / 1) THF, -78 deg C, 15 min; -40 deg C, 0.5 h, 2) THF, -78 deg C, 15 min
6: 2,6-lutidine / CH2Cl2 / 2 h / 0 °C
7: 1.1 g / K2CO3 / methanol / 0.25 h / 25 °C
8: 78 percent / TBAF / tetrahydrofuran / 8 h / 25 °C
9: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-DMAP / 1) THF, 0 deg C, 15 min, 2) toluene, 25 deg C, 0.5 h
10: 92 percent / CF3CO2H / CH2Cl2 / 1) -20 deg C -> 0 deg C, 2) 0 deg C, 1 h
View Scheme
参考文献
Nicolaou; Ninkovic; Sarabia; Vourloumis; He; Vallberg; Finlay; Yang
Journal of the American Chemical Society, 1997 , vol. 119, # 34 p. 7974 - 7991
