ammonia in methanol T=20°C; 12 h;

1.1: POCl3 / acetonitrile / 0.17 h / 0 °C 1.2: Et3N / acetonitrile / 0.33 h / 0 °C 1.3: 91 percent / acetonitrile / 20 °C 2.1: 86 percent / HONH2*HCl; pyridine / 12 h / 20 °C 3.1: 81 percent / NH3 / methanol / 12 h / 20 °C View Scheme