1: 99 percent / H2 / 10percent Pd/C / methanol / 3 h / 1551.4 Torr / Ambient temperature 2: 89 percent / DMAP View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: BF₃*MeOH / CH₂Cl₂ / Ambient temperature<br />2: NEt₃ / CHCl₃ / Ambient temperature<br />3: acetonitrile; CHCl₃ / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) K / 1.) C₆H₆, reflux, 4 h, 2.) C₆H₆, reflux, overnight<br />2: 1.) POCl₃, Et₃N, 2.) pyridine / 1.) CHCl₃, 60-65 deg C, 30 min, 2.) CHCl₃, RT, 5 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 87 percent / H₂SO₄ / H₂O; ethanol / 5 h / Heating<br />2: 1.) K / 1.) C₆H₆, reflux, 4 h, 2.) C₆H₆, reflux, overnight<br />3: 1.) POCl₃, Et₃N, 2.) pyridine / 1.) CHCl₃, 60-65 deg C, 30 min, 2.) CHCl₃, RT, 5 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 1.) K / 1.) C₆H₆, reflux, 7 h, 2.) C₆H₆, reflux, overnight<br />2: 87 percent / H₂SO₄ / H₂O; ethanol / 5 h / Heating<br />3: 1.) K / 1.) C₆H₆, reflux, 4 h, 2.) C₆H₆, reflux, overnight<br />4: 1.) POCl₃, Et₃N, 2.) pyridine / 1.) CHCl₃, 60-65 deg C, 30 min, 2.) CHCl₃, RT, 5 h<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1731042', constants.ctx, '0')">chloroform</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635639', constants.ctx, '0')">isopropyl alcohol</a> <br />T=50&deg;C;&nbsp;12&nbsp;h;&nbsp;<br /> &nbsp;