(3S,4s)-(-)-1-苄基-3,4-二羟基吡咯烷-2,5-二酮合成路线 (共 6 条)
反应条件
1: in methanol; water T=50°C; 2: in xylene T=190°C; 8 h;
参考文献
Rejman, Dominik; Kocalka, Petr; Budesinsky, Milos; Pohl, Radek; Rosenberg, Ivan
Tetrahedron, 2007 , vol. 63, # 5 p. 1243 - 1253
反应条件
1: 67 percent / NaBH4; BF3*Et2O 2: 95 percent / HN3; DEAD; PPh3 3: LiAlH4 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Skarzewski, Jacek; Gupta, Anil
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1861 - 1867
反应条件
1: 67 percent / NaBH4; BF3*Et2O 2: 95 percent / HN3; DEAD; PPh3 3: LiAlH4 / tetrahydrofuran / 0.5 h / Heating 4: 1.5 g / NaOH / H2O; dioxane / 2 h / 20 °C View Scheme
参考文献
Brouwer, Arwin J.; van Der Linden, Heiko J.; Liskamp, Rob M. J.
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1750 - 1757
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 12 h; Heating;
参考文献
Bridgeman, Eve; Cavill, Julie L.; Schofield, Daniel J.; Wilkins, Derek S.; Tomkinson, Nicholas C. O.
Tetrahedron Letters, 2005 , vol. 46, # 49 p. 8521 - 8524
反应条件
hydrogenchloride; sodium hydroxide; sodium borohydride; sodium fluoride in diethylene glycol dimethyl ether
参考文献
Novo Nordisk A/S
Patent: US5952363 A1, 1999 ;
反应条件
1: 67 percent / NaBH4; BF3*Et2O
2: 95 percent / HN3; DEAD; PPh3
View Scheme
参考文献
Skarzewski, Jacek; Gupta, Anil
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1861 - 1867