Boc-反式-3-羟基-l-脯氨酸合成路线 （共 11 条）
反应条件
1: With sodium hydroxide in water T=20°C; 2 h; 2: With hydrogenchloride in water T=0 - 10°C; pH=4;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 35-36 ;
反应条件
sodium hydroxide in tetrahydrofuran T=20°C;
参考文献
Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano
Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7280 - 7282
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Sun, Chongqing; Robl, Jeffrey A.; Salvati, Mark E.; Wang, Tammy; Hamann, Lawrence; Augeri, David
Patent: US2003/55094 A1, 2003 ;
US 20030055094 A1
反应条件
triethylamine in 1,4-dioxane; methanol; water T=20°C; 4 h;
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
in methanol; dichloromethane
参考文献
Abbott Labaoratories
Patent: US2010/267634 A1, 2010 ;
反应条件
1: diethyl ether 2: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 3: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 90°C; 2 h;
参考文献
TETRALOGIC PHARMACEUTICALS CORP.; CONDON, Stephen, M.; LAPORTE, Matthew, G.
Patent: WO2010/33531 A1, 2010 ;
Location in patent: Page/Page column 66 ;
反应条件
in methanol; diethyl ether T=20°C; 0.25 h;
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
in tetrahydrofuran; methanol; diethyl ether T=0°C; 2 h; Product distribution / selectivity;
参考文献
Vicuron Pharmaceuticals Inc.
Patent: US2010/22605 A1, 2010 ;
Location in patent: Page/Page column 16; 33; 36 ;
US 20100022605 A1
反应条件
1.1: diethyl ether 2.1: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 3.1: aq. NaOH / tetrahydrofuran / 1 h 4.1: Cs2CO3 / dimethylformamide / 0 °C 4.2: 5.3 g / dimethylformamide / 20 °C 5.1: morph-DAST / tetrahydrofuran / -78 - 20 °C 6.1: H2 / Pd/C / methanol 7.1: HCl / dioxane / 1.5 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
