2-三氟甲基喹啉-4-羧酸合成路线 （共 11 条）
反应条件
sodium hydroxide; zinc in water T=0°C; 2 h;
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.75 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
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Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
potassium hydroxide; sodium acetate in water; acetic acid
反应条件
sodium acetate; acetic acid in ethanol; water
反应条件
1: 88 percent / phosphorus oxybromide / 2 h / 150 °C 2: 74 percent / butyllithium / tetrahydrofuran; hexane / 0.75 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
反应条件
1: 51 percent / polyphosphoric acid / 2 h / 150 °C 2: 88 percent / phosphorus oxybromide / 2 h / 150 °C 3: 74 percent / butyllithium / tetrahydrofuran; hexane / 0.75 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
反应条件
1: 64 percent / polyphosphoric acid / 2 h / 150 °C 2: 83 percent / phosphorus oxybromide / 2 h / 150 °C 3: 69 percent / butyllithium; iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 4: 45 percent / isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 5: 100 percent / zinc; sodium hydroxide / H2O / 2 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
反应条件
1: 83 percent / phosphorus oxybromide / 2 h / 150 °C 2: 69 percent / butyllithium; iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 3: 45 percent / isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 4: 100 percent / zinc; sodium hydroxide / H2O / 2 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
反应条件
1: 69 percent / butyllithium; iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 2: 45 percent / isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 3: 100 percent / zinc; sodium hydroxide / H2O / 2 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
反应条件
1: 45 percent / isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 2: 100 percent / zinc; sodium hydroxide / H2O / 2 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1576 - 1588
