4-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸合成路线 （共 21 条）
反应条件
potassium hydroxide; water in methanol T=-78 - -20°C; 3.75 h; Heating / reflux;
参考文献
ALANTOS PHARMACEUTICALS HOLDING, INC.
Patent: WO2008/63671 A2, 2008 ;
Location in patent: Page/Page column 177-178 ;
WO 2008/063671 A2
反应条件
1: 88.9 percent / BF3*Et2O / acetic acid / 24 h 2: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating 3: 44.9 percent / KOH / methanol; H2O / 24 h View Scheme
参考文献
Synthesis, , # 1 p. 71 - 76
反应条件
1: 1.) NaH / 1.) 1,2-dimethoxyethane, 2.) 1,2-dimethoxyethane, reflux 2: 88.9 percent / BF3*Et2O / acetic acid / 24 h 3: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating 4: 44.9 percent / KOH / methanol; H2O / 24 h View Scheme
参考文献
Synthesis, , # 1 p. 71 - 76
反应条件
1: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating 2: 44.9 percent / KOH / methanol; H2O / 24 h View Scheme
参考文献
Synthesis, , # 1 p. 71 - 76
反应条件
1: 72 percent / LDA, HMPA / tetrahydrofuran / -78 deg C to RT 2: 50 percent / KOH / methanol; H2O / 24 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 781 - 784
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile 96 h; Ambient temperature;
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1079 - 1087
反应条件
1: H2SO4 / CH2Cl2 / 24 h / Heating 2: 78 percent Turnov. / NaIO4, RuCl3*H2O / H2O; acetonitrile; CCl4 / 96 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 7 p. 1079 - 1087
反应条件
2: Py / Heating 3: 165 °C / 760000 Torr 4: H2 / Pd-C 5: aq. KOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 35, p. 917 - 923
反应条件
1: Py / Heating 2: 165 °C / 760000 Torr 3: H2 / Pd-C 4: aq. KOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 35, p. 917 - 923
反应条件
1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere 2.1: potassium hydroxide; water / methanol / 24 h / Reflux 2.2: pH 3 View Scheme
