4-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸合成路线 （共 21 条）
反应条件
1: 62 percent / BF3*THF / tetrahydrofuran / 16 h / 20 °C
2: 37 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C
3: 89 percent / aq. lithium hydroxide / tetrahydrofuran / 16 h / 20 °C
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参考文献
BIOGEN IDEC MA INC; KWOK, Daw-long, Albert; KIESMAN, William; HUMORA, Michael; CAI, Xiongwei; LITTKE, Adam; CHANG, HeXi
Patent: WO2011/63268 A2, 2011 ;
